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Semaglutidethe GLP-1 receptor agonist originally developed for type 2 diabeteshas transformed weight management, with clinical trials showing patients lose 15% of body weight on average
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In TRANSCEND-T2D-1 (type 2 diabetes): nausea 26.5%, diarrhea 22.8%, vomiting 17.6%, dysesthesia 4.4%
The key difference is that maintenance therapy is not about ongoing weight lossit is about preventing weight regain by continuing to modulate appetite-regulating hormones in the brain and gastrointestinal tract
Semaglutide meds such as Ozempic or Wegovy can help patients lose weight and slightly lower their risk of having a cardiovascular event, but due to the potential side effects and cost, these medications are definitely not first-line treatments for most people with cardiovascular disease
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